However, a recent useful systematic review and meta-analysis specifically analyzed the immunological outcomes of BC supplementation in trained and physically active people, and reported that BC supplementation has no or a fairly low impact on improving the concentration of serum immunoglobulins (IgA and IgG), lymphocytes and neutrophils, and salivary immunoglobulin (IgA) [8]. This evidence concerns the gene CD79A and breast cancer.