Finally, a multiethnic meta-analysis of various types of cancer with 9926 cases in 10 studies (prostate, lung, colorectal, skin, glioma, and head and neck) for VDR rs1544410 and 11,334 cases in 12 studies (breast, prostate, lung, colorectal, skin, glioma, ovarian, and head and neck) for VDR rs2228570 evaluated the association of these two polymorphisms with OS. Here, VDR is linked to central nervous system cancer.