This study found that the CYP27B1 rs4646535, CYP24A1 rs6068816, GC rs7041, VDR rs11568820, VDR rs731236, and VDR rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease. The gene discussed is CYP27B1; the disease is non-small cell lung carcinoma.