A higher risk of progression was shown in non-resected NSCLC patients carrying the A allele for the CYP27B1 rs4646536 gene polymorphism compared to those with the GG genotype (p = 0.0443; HR = 2.05; CI95% = 1.02–4.14; Table S16). Here, CYP27B1 is linked to non-small cell lung carcinoma.