Within this system, long-chain fatty acids in chylomicrons undergo the surveillance of C-X3-C motif chemokine receptor 1 (CX3CR1)-expressing macrophages residing in the villi, the CD103/CD11b expressing DCs (representing up to 80% of the total population of gut resident DCs) [84,85], and the innate lymphoid cell family member 2 (ILC2) [86] (a subset that uses dietary fatty acids as fuel for cellular fatty acid oxidation and energy production to produce IL-5, IL-9, IL-13 against Trichuris muris helminth infection [87]). The gene discussed is CX3CR1; the disease is helminthiasis.