TNFSF11 and cardiovascular disorder: For example, both TRANCE and CX3CL1/fractalkine have been recognized as inflammatory mediators involved in the progression of cardiovascular disease through associations with increased expression of inflammatory factors (Intercellular adhesion molecule-1; ICAM-1, vascular cell adhesion molecule-1; VCAM-1) and roles in platelet activation and monocyte recruitment of the vascular wall [21,22].