In a rat model of NEC, soybean-derived EGF supplementation has been shown to improve intestinal barrier function, to reduce the expression of pro-inflammatory proteins Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (iNOS), and to decrease the incidence of intestinal injury [44]. The gene discussed is NOS2; the disease is necrotizing enterocolitis.