Under normal circumstance, the thyroid gland of a healthy individual is expected to encompass 70–80% of the total iodine in the body, which is about 15–20 mg while the body uses about 80 μg to produce thyroid hormones In the case of deficiency, the hypothalamus–pituitary–thyroid pathway becomes activated such that the volume of the thyroid gland increases until goiter becomes obvious, to be managed with surgery and replacement of thyroid hormone [35]. This evidence concerns the gene TG and hyperinsulinemic hypoglycemia, familial, 4.