To establish the mechanism through which testosterone contributes to iron homeostasis, Dhindsa et al. (2016) assessed certain iron-related biomarkers before and after hormonal therapy for males with hypogonadotropic/hypogonadism revealing that there was a positive relation between testosterone and erythropoietin, as well as the gene expression of ferroportin versus negative relationship with hepcidin [67]. This evidence concerns the gene HAMP and hypogonadism.