The effect on the NADP(H) level of CD38 pharmacological inhibition was investigated in an ex vivo model of myocardial ischemia/reperfusion injury: endothelial NADP(H) levels were greatly decreased in postischemic conditions, whereas in the presence of 78c (a CD38 inhibitor), the decrease in NADP(H) levels, was greatly reduced [74]. Here, CD38 is linked to myocardial ischemia.