Nutritional supplementation with ME7, ME10- and/or exercise training was able to facilitate a lowered circulating concentration of cytokines which have been associated with obesity (including IL-6 [106,107], IL-7 [108], and IL-8 [109]), which was mirrored by lowered mRNA expression of these markers in WAT. Here, CXCL8 is linked to obesity due to melanocortin 4 receptor deficiency.