DNMT1 and breast cancer: SFN reduced the expression of DNMT1 and DNMT3B in three breast cancer cell lines (MCF-7, MDA-MB- 231, and SK-BR-3) with a significant increase in the expression of p21 and p27, and down-regulation of miR-23b, miR-92b, miR-381, and miR-382 [137].