Consequently, BBR not only induced the inhibition of DNMT1 mRNA, protein, and promoter activity, but also reduced 3-phosphoinositide-dependent protein kinase-1 (PDPK1) and transcription factor SP1 protein expressions as well as the inhibition of growth, migration, invasion, and induction of cell cycle arrest in lung cancer cells. The gene discussed is PDPK1; the disease is lung cancer.