UA might interact with USP7 in RPMI8226 human myeloma cells and could inhibit myeloma cell proliferation (IC50 = 6.56 μmol/L), accompanied by reductions in USP7 substrates such as MDM2, UHRF1, and DNMT1 related to the inhibition of USP7. Here, USP7 is linked to plasma cell myeloma.