Consequently, BBR not only induced the inhibition of DNMT1 mRNA, protein, and promoter activity, but also reduced 3-phosphoinositide-dependent protein kinase-1 (PDPK1) and transcription factor SP1 protein expressions as well as the inhibition of growth, migration, invasion, and induction of cell cycle arrest in lung cancer cells. Here, DNMT1 is linked to lung carcinoma.