In prostate cancer cells, the decrease in DNMT expression by SFN induces re-expression of several hypermethylated genes, such as TGFBR1 and CYR61 [16], while reactivation of Nrf2 by SFN leads to Nrf2-induced NQO-1 expression, a protein that plays a key role in antioxidant protection [126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156]. This evidence concerns the gene DNMT1 and Familial prostate cancer.