In the context of highlighting the epigenetic potential of BBR against cerebral ischemia, Pang et al. [14] found that BBR decreases the expressions of DNMT1 and DNMT3a and reduces methylation of the PPARγ promoter region, regulates the expression of the peroxisome proliferator-activated receptor (PPARγ), and also increases PPARγ expression during cerebral ischemia-reperfusion. The gene discussed is DNMT3A; the disease is brain ischemia.