After treating human hepatocellular carcinoma cells HepG2 with UA, Yie et al. [109] observed a significant inhibition of HCC cell growth and induction of apoptosis depending on the dose and time, as well as the activation of phosphorylation of AMPKα and the suppression of the protein expression of DNMT1 in a dose-dependent manner. Here, DNMT1 is linked to hepatocellular carcinoma.