DNMT1 and hepatocellular carcinoma: Similar to these findings, treatment with GE and TSA has been reported to inhibit cell growth at all concentrations used, down-regulate the DNMT1 gene expression after 48 and 72 h, and DNMT3a gene expression only after 72 h, but also induces apoptosis in all treatment groups tested on human hepatocellular carcinoma (HepG2) cells [81].