Furthermore, Moon et al. [33] evaluated in their research the possible epigenetic therapy of vincristine and its impact on the methylation status of the runt-related transcription factor-3 (RUNX3) gene involved in colorectal cancer, using DLD-1 colorectal adenocarcinoma cells and CCD18Co normal colon cells. This evidence concerns the gene RUNX3 and colorectal adenocarcinoma.