Li et al. [41] evidenced that GE (25 μM), when combined with TSA (100 ng/mL), exhibited potential effects in preventing breast cancer; it enhanced the re-expression of ERα expression in MDA-MB-231 cells, induced the resensitization and reactivation of ERα-negative breast cancer cells to E2 and tamoxifen (TAM) antagonist, and also promoted histone remodeling changes in the ERα promoter. This evidence concerns the gene ESR1 and breast cancer.