For ITT, FO-FO and HF-FO groups showed improved insulin sensitivity similar to LF-LF groups for both male and female mice, and most importantly FO-FO and HF-FO and LF-LF groups were clearly separated from HF fed groups (HF-HF and FO-HF) from 30-min time point onwards (Figure 3E,F). Here, INS is linked to hydrops fetalis.