The present transcriptome profiling extends previous findings in high-fat diet-induced obesity models in the mouse, where lingonberry has been reported to prevent liver triacylglycerol deposition and enhance insulin clearance, to downregulate acute-phase and inflammatory pathways in the liver, to activate liver Akt and AMPK pathways and to improve hepatic steatosis [19,29,64,65]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.