Liver injury and regeneration have also been correlated to complex ECM-related pathways, and several works [14] have suggested that MMP-9, and particularly MMP-2 (generally known as gelatinases), fulfill important roles in liver inflammation, fibrosis, and cancer, with enough studies justifying the rationale to search for inhibitors to specifically target MMP-2 and -9 in liver. This evidence concerns the gene MMP9 and cancer.