Extending this approach of targeted treatment, Yang et al. employed the chemotherapeutic agent irinotecan (a topoisomerase inhibitor) as well as anti-CD133 antibodies targeting CD133, a surface structure overexpressed by cancer stem cells, onto targeted SPIONs to achieve targeted thermo-chemotherapy, which resulted in potent tumor growth inhibition significantly surpassing the effects of either treatment alone [42]. This evidence concerns the gene PROM1 and neoplasm.