Yang et al. showed efficient targeting of SPION-containing ML, which are SPIONs encapsulated with phospholipids for increased biocompatibility, by modification with anti-CD90-antibodies resulting in improved tumoricidal effects against CD90-positive Huh7 hepatocellular cancer cells, a liver cancer stem cell line, in terms of apoptosis-related cytotoxicity and tumorigenic ability. Here, THY1 is linked to hepatocellular carcinoma.