For an illustration of representative cases of PMLA-based mini-nano devices, four applications for mouse models are presented: (1) permeation through the BBB with the potential for imaging and cascade drug delivery in the treatment of tumor and neurodegenerative diseases, (2) high-intensity fluorescence imaging of tumor for guided resection of glioblastoma, (3) identification of tumors by MRI, and (4) the efficacy of nano drugs for inhibition of human HER-2 positive breast cancer. This evidence concerns the gene ERBB2 and breast carcinoma.