TNF and infection: Studies show a strong correlation between diabetic patients and the incidence of peri-implant infection [6,7,8,9], as well as reduced osseointegration [10], as impaired glycemic control increases the release of toxic metabolites (advanced glycation end products AGEs) [11], and inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α), which lead to a slowed healing process for dental implants, and subsequent infection and implant failure (Figure 1) [12,13].