This outcome concerns 28 clinical trials for vaccines (e.g., a peptide vaccine that targets EGFRvIII or IDH1), 13 clinical trials for oncolytic viruses, 15 phase III clinical trials for checkpoint inhibitor mAbs (e.g., CheckMate 143 trial), and CAR-T cells, none of which have surpassed the efficacy of GBM standard-of-care, that is, temozolomide/radiation therapy, with 14.6 months of average survival [53]. This evidence concerns the gene IDH1 and glioblastoma.