In the heart, spleen, and kidney, the biodistribution of PT-R-Ms was significantly lower while high fluorescent micelles were accumulated in the excised tumor, as depicted in Figure 12B. When the uptake of PT-R-Ms in the tumor was compared to other organs, significantly higher distribution was found due to the presence of papain enzyme that degrades the ECM present in the tumor tissue, thus allowing the penetration of micelles deep into the tumor tissue, hence hindering the absorption of the therapeutic entity and its specificity towards the target. The gene discussed is PTCHD3; the disease is neoplasm.