Proinflammatory cytokine, such as the mentioned H. pylori-related TNF-α and IL-6, have been revealed to regulate the expression of the mentioned RAAS components, especially angiotensinogen production in the liver and kidneys, further promoting systemic and local angiotensin II formation and angiotensin II-dependent hypertension [182]. The gene discussed is AGT; the disease is Hypertension.