Although the pathogenesis of arterial hypertension is not entirely understood, there is support for the idea that its pathogenesis predominantly consists of a noxious interplay among vascular, renal, neural, and hormonal mechanisms, of which increased activation of the sympathetic nervous system (SNS) and the renin–angiotensin–aldosterone system (RAAS) prevail [8]; RAAS dysregulation, including the systemic and brain RAAS, has been recognized as one of the main causes of several types of arterial hypertension [9]. Here, REN is linked to Hypertension.