Focusing on BMI, some other investigators reported that H. pylori eradication seems to restore ghrelin by increasing gastric ghrelin secretion, leading to increased plasma ghrelin levels, increased appetite and a rise in BMI, though a causative relationship between H. pylori-connected serum ghrelin decline and food intake and obesity has not been established. Here, GHRL is linked to obesity due to melanocortin 4 receptor deficiency.