Specifically, CagA (cytotoxin-associated gene A) is a critical H. pylori virulence factor connected with a greater inflammatory response [100,101] and H. pylori-related CagA could especially be involved in the development of atherosclerosis [102]; by introducing polymerase chain reaction (PCR), H. pylori DNA has been detected in the atherosclerotic plaques of patients with severe coronary artery disease, and H. pylori infection accompanying the expression of CagA proteins is significantly connected with coronary artery disease. The gene discussed is S100A8; the disease is atherosclerosis.