AD is a neurodegenerative disease characterized by memory loss and a progressive loss of cognitive function involving the extracellular accumulation of pathogenic amyloid-β (Aβ) peptides that oligomerize and aggregate, forming plaques [9], and the intracellular accumulation of hyperphosphorylated tau proteins that form neurofibrillary tangles [10]. The gene discussed is MAPT; the disease is Alzheimer disease.