Considering that patients with infiltrative pulmonary TB against the background of HIV infection may have elements of destructive decay that are not detected radiologically but are reflected in the immune response, an increased level of IL-6 expression against the background of reduced concentrations of IL-4 and IL-10 can serve as a marker for the early detection of M. tuberculosis infection in HIV-infected individuals. This evidence concerns the gene IL6 and pulmonary tuberculosis.