Whilst the levels of some cytokines (i.e., IL-6, IL-8, IP-10, TNF-α, sCD25) declined one month after the SARS-CoV-2 diagnosis, others (MIP-1β, IL-1β, MIP-1α and IFN-γ) showed higher levels at month 1 and/or 3 in patients with mild/moderate disease compared to those with severe COVID-19. The gene discussed is IL6; the disease is COVID-19.