The level of IL-6 was significantly increased to 4816.65 pg/mL (at 3 h after infection) and 5223.36 pg/mL (at 5 h after infection) in HTB-5 cells infected with purified FimH protein compared with uninfected cells (2602.9 pg/mL at 3 h after infection and 3121.87 pg/mL at 5 h after infection) and HTB-5 cells infected with UPEC CFT073 (1540.96 pg/mL at 3 h after infection and 967.25 pg/mL at 5 h after infection) (Figure 3a). The gene discussed is IL6; the disease is infection.