Various other biomarkers of TB treatment response have been identified, including serum proteins such as C-reactive protein, IL-1β, IL-6, matrix metalloproteinase-8 (MMP-8), procalcitonin, pentraxin 3 and serum amyloid A1, all of which were strongly associated with baseline TB severity and modulated by TB treatment [122]. This evidence concerns the gene IL6 and tuberculosis.