Although causality with prior infection cannot be clearly established, the results are consistent with a number of previous studies in patients with complicated forms of Lyme disease and post-Borreliosis syndrome, in which antibodies to a variety of autoantigens were found, such as annexin A2 [75], apolipoprotein B-100 [76], endothelial cell growth factor [77], matrix metalloproteinase-10 [78], phospholipids [79], cyclophilin [80], neural tissue [81,82], γ-enolase [83], ANA, and myositis-associated antibodies [47]. This evidence concerns the gene ANXA2 and Lyme disease.