In particular, the germline-encoded NK receptors include the activating receptors for the elimination of tumor cells, namely NKG2D, DNAM-1, NKp80, CD2, and Tim-3; the natural killing receptors NKp30, NKp44, and NKp46; the signaling lymphocyte activating molecule (SLAM) family (2B4, NTB-A, and CRACC); and MHC-dependent KIRs (KIR2DS, KIR3DS) and CD94/NKG2C. This evidence concerns the gene KLRD1 and neoplasm.