Since patients with ACE2 autoantibodies also had less plasma ACE2 activity, these authors hypothesized that the ACE2 autoantibodies were anti-idiotypic antibodies that could interfere with ACE2 function and contribute to post-acute sequelae of SARC-CoV-2 infection (PASC, or “long-COVID”). The gene discussed is ACE2; the disease is COVID-19.