The NETs accumulated in distant organs are shown to influence the recruitment of CTCs via chemotaxis, as observed in liver metastasis in breast cancer and colon cancer patients where coiled-coil domain-containing protein 25 (CCDC25), a transmembrane protein, acts as an attractant of the NET-associated chemotactic factors [69] and also initiates the β-parvin–RAC1–CDC42 cascade further supporting cytoskeleton rearrangement and directional migration of tumor cells [69]. This evidence concerns the gene CCDC25 and malignant colon neoplasm.