Since IFN-γ and IL-4 are the signature cytokines of Th1 and Th2 immune responses, respectively, this work proposes investigating the significance of IFN-γ and IL-4 in predicting the therapeutic outcome when bivalent HPV vaccine immunotherapy is applied to patients with cutaneous and anogenital warts. Here, IL4 is linked to anogenital human papillomavirus infection.