In a recent pre-clinical study, co-immunization of an AD mouse model with intact Aβ(1-42) together with bee venom phospholipase A2 (bvPLA2) showed that bvPLA2 induces regulatory T cells (CD4+ CD25+ Foxp3+ T cells, Tregs) and ameliorates AD pathology, without undesirable T cell-mediated inflammation. Here, CD4 is linked to Alzheimer disease.