NR3C1 and infection: Of note, blockage of GR and PR by RU-486 was associated with higher levels of IL-22 than in untreated control explants irrespectively of the MPA dose administered prior to infection (Figure 3A), resulting in a statistically significant difference between both MPA 100 and 10 nM and the related RU-486 control (pre-infection, Figure 3C).