It has been demonstrated that hypoxia-inducible factor-1α (HIF-1α) is a direct transcriptional suppressor of interferon regulatory factors (IRFs), the transcriptional activators of type-I IFN, and hypoxia suppresses type-I IFN but not NF-κB-dependent pro-inflammatory cytokine production [74], which may at least partly explain COVID-19 pathogenesis. This evidence concerns the gene HIF1A and COVID-19.