TARDBP and amyotrophic lateral sclerosis: In particular, 24.44% of ALS patients showed Abs against TDP-43(258–271), whereas only 4.44% in the healthy group showed a humoral response against the same peptide (Figure 1B): Mann–Whitney U test, p < 0.0001, HCs median = 0.157, 95% CI [0.084, 0.191], ALS median = 0.284, 95% CI [0.243, 0.318]; cut off value of 0.381; Fisher’s exact test, p = 0.013; and AUC = 0.813.