TARDBP and amyotrophic lateral sclerosis: Figure 1D shows the antibody response against TDP-43(398–411)P; only 4.44% of healthy subjects were positive, whereas in ALS patients, we observed an increased percentage of up to 20.00% (Mann–Whitney U test, p = 0.0006, HCs median = 0.151, 95% CI [0.103, 0.195], ALS median = 0.226, 95% CI [0.202, 0.255]; cut off value of 0.35; Fisher’s exact test, p = 0.049; and AUC = 0.706).