Likewise, Conti et al., documented increased levels of both anti-TDP-43 Abs and TDP-43 protein in ALS-serum patients compared with healthy controls, motor neuron disease mimics, and Alzheimer’s and frontotemporal lobar degeneration patients, but autoantibodies and protein serum levels failed to correlate [36]. Here, TARDBP is linked to frontotemporal dementia.