TNF and infection: At day 15 post Ad-HBV-Luc infection with 107 pfu/mouse, during the ongoing anti-viral effector function, we detected high numbers of IFNγ and TNF producing CD8 T cells after restimulation by both Cor93 and SIINFEKL peptide, indicating that these T cells have been stimulated already at this time point during virus elimination in vivo (Figure 4A).