This finding is concordant with data from androgen-mediated increases in ACE2 expression in human embryonic stem cell-derived cardiac cells and human primary alveolar epithelial cells and androgen-mediated regulation of TMPRSS2 in prostate cancer [59,60], supporting a hypothesis that higher ACE2 and TMPRSS2 expression are related to poorer prognosis in men infected with COVID-19. This evidence concerns the gene TMPRSS2 and COVID-19.