However, humanized mice that received medium and high doses (GRUs) of the virus developed fatal B cells lymphoma even though there were large amounts of hCD8+ T cells in the peripheral blood and spleens, which indicated that an EBV-induced CD8+ T cell response was not sufficient to control the occurrence and development of EBV-induced lymphoma. Here, CD8A is linked to B-cell non-Hodgkin lymphoma.