The IRE1 activation marker XBP1 was strongly induced in neuronal SH-SY5Y and intestinal Caco-2 cells upon infection with all three TBFV and in astrocytoma SNB19 cells upon infection with TBEV Neudoerfl (Figure 2A–C). The gene discussed is XBP1; the disease is astrocytoma (excluding glioblastoma).