Infections with the mosquito-borne flaviviruses (MBFV) dengue virus (DENV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) as well as infection with the tick-borne flavivirus (TBFV) Langat virus (LGTV) have been demonstrated to lead to an increased expression of BiP [14,15,17,22,23]. This evidence concerns the gene HSPA5 and infection.