Zheng and colleagues reanalyzed the expression of MyD88 and TLRs in patients with different severity grades of COVID-19 using a public dataset and found that the expression of MyD88, TLR1, TLR2, TLR4, TLR5, TLR8, and TLR9 was increased in patients with severe to critical illness. This evidence concerns the gene TLR4 and COVID-19.