Zheng and colleagues reanalyzed the expression of MyD88 and TLRs in patients with different severity grades of COVID-19 using a public dataset and found that the expression of MyD88, TLR1, TLR2, TLR4, TLR5, TLR8, and TLR9 was increased in patients with severe to critical illness. The gene discussed is MYD88; the disease is COVID-19.