DICER1 and viral infectious disease: RNAi also possesses an antiviral role in human neural progenitors and pluripotent stem cells [115,116] as antiviral Dicer (aviD), an isoform of Dicer has been shown to protect stem cells from RNA viral infections [117]; however, RNAi becomes inactive in differentiated human cells in which the IFN response is active, which highlights intrinsic differences in innate immunity between pluripotent and differentiated cells [118,119].