RHOV and Zika virus infectious disease: We found that G40V and G40V/C234S mutants increased ZIKV infection at 24 h.p.i. but to significantly lower levels compared to WT RhoV, suggesting that the proviral effects are likely dependent on an optimal level of RhoV activation similar to what was previously reported for other Rho GTPases in PDGF-induced cell invasion and transformation [38,39].