The FPPS (Figure 5B) gene, which is an enzyme for sesquiterpenes precursor biosynthesis, was significantly up-regulated by infection in cones of the Saaz (2.3 times) cultivar but non-significantly down-regulated by infection in cones of the Sládek (1.8 times), Premiant (1.6 times), and Agnus (1.4 times) cultivars. The gene discussed is FDPS; the disease is infection.