Newer syndromic PPGL genes include FH (Hereditary Leiomyomatosis and Renal Cell Cancer syndrome), EPAS1 (mainly as a case of germline mosaicism, although EPAS1 mutations are generally more common as somatic mutations) and EGLN1 (associated with congenital polycythaemia). This evidence concerns the gene EPAS1 and hereditary leiomyomatosis and renal cell cancer.