In our study, variant IVS2 + 1G > A of APOC3 was detected in a 65-year-old subject (patient P59) with hypercholesterolemia (total cholesterol 8.2 mmol/L, LDL-C 5.45 mmol/L) and normal levels of triglycerides (0.7 mmol/L) and HDL-C (2.4 mmol/L), with a DLCN score of 5. Here, APOC3 is linked to Hypercholesterolemia.