IL5 and childhood onset asthma: Childhood asthma was subdivided into pheno- and endo-types according to: (i) epigenetic methylation of DNA and histones [125]; (ii) Th1 and Th2 cytokines [126,127]; (iii) comorbidities and response to treatment [128,129]; (iv) interferon γ/interleukin-5(IL-5)/IL-17 predominance [130]; (v) wheezing, atopy, and respiratory morbidity [131].