Also, variant rs1799752 in the gene coding for the Angiotensin Converting Enzyme (ACE) has been linked to the effectiveness of some ACE inhibitors, such as captopril [87] and enalapril, [88] and to spironolactone; patients with del/del genotype and chronic heart failure may have less improvement in left ventricular ejection fraction, end-systolic and end-diastolic volume [89]. The gene discussed is ACE; the disease is congestive heart failure.