With the LASSO logistic regression model, 20 hub genes (SPP1, MTHFD2, SLC20A1, TRIP13, PLA2G7, MKI67, ENO2, MICAL2, MMP9, GSTM5, GALNT2, STAG1, TSPAN31, ECHDC2, ATP10D, PAMR1, SLC24A3, GULP1, ID4, and KLF4) were identified and could effectively distinguish between gynecologic cancer and normal tissues. The gene discussed is MKI67; the disease is female reproductive organ cancer.