Regarding our primary endpoint, using a univariate analysis of age (p = 0.03), NYHA class (p < 0.001), CHA2DS2-Vasc score (p < 0.001), glomerular filtration rate (GFR) (p = 0.007), arterial hypertension (p = 0.004), presence of coronary artery disease (p = 0.001), presence of non-ischemic (versus ischemic) cardiomyopathy (NICM; p = 0.01), clinical response to resynchronization therapy (p = 0.008), and NT-proBNP (p < 0.001), the results showed a significant association with survival. Here, NPPB is linked to ischemic cardiomyopathy.