IDE and type 2 diabetes mellitus: Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1)_rs163177, CDK5 regulatory subunit associated protein 1, such as 1 (CDKAL1)_rs10946398 and rs7754840, insulin-degrading Enzyme (IDE)_rs4646957, ATP binding cassette transporter 1 (ABCA1)_rs4149313, and hematopoietically-expressed homeobox protein (HHEX)_rs5015480, which are mainly involved in insulin secretion and β-cell survival, are reported to be associated with T2DM [11,12,13].