We found that genetically proxied PCSK9 could decrease the risk of aortic aneurysms in the UK Biobank cohort (OR = 0.63, 95% CI = 0.46–0.85, p = 3.2 × 10−3); however, this was not replicated in the FinnGen cohort (OR = 0.87, 95% CI = 0.69–1.10, p = 0.24). The gene discussed is PCSK9; the disease is aortic aneurysm.