Furthermore, we assessed the association of LDL-C-lowering targets, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), Niemann-pick C1-like 1 (NPC1L1), proprotein convertase subtilisin/kexin type 9 (PCSK9), cholesteryl ester transfer protein (CETP), and low-density lipoprotein receptor (LDLR) and TG-lowering targets of angiopoietin-like 3 (ANGPTL3) and lipoprotein lipase (LPL) with aneurysms. This evidence concerns the gene NPC1L1 and aneurysm.