The MR analysis revealed an association between genetically proxied LDL-C-lowering inhibition of HMGCR with lower risks of aortic aneurysms (OR = 0.34, 95% CI = 0.24–0.49, p = 1 × 10−5) and abdominal aortic aneurysms (OR = 0.31, 95% CI = 0.16–0.62, p = 8.51 × 10−4). The gene discussed is HMGCR; the disease is aortic aneurysm.