As a result, multifocal tumor (HR: 1.76, 95% CI: 0.31–8.12, p = 0.05), incomplete resection (HR: 2.91, 95% CI: 0.31–27.07, p = 0.01), MGMT unmethylation (HR: 0.79, 95% CI: 0.11–6.25, p = 0.03) and PTV >200 cc (HR: 1.99, 95% CI: 0.26–5.37, p = 0.05) were significant negative prognostic factors for disease progression. The gene discussed is MGMT; the disease is neoplasm.