AFP and neoplasm: According to multivariate analysis results of discovery cohort, disease free survival was positively associated (i.e., Hazard Ratio (HR) < 1) with 7-gene signature (HR 0.454, CI 0.291–0.710, p = 0.001), AFP (HR 0.573, CI 0.352–0.935, p = 0.026), while negatively associated (i.e., HR > 1) with tumor number (HR 5.895, CI 2.621–13.259, p = 0.000) (Table 3).