According to the statistical analysis results, several HLA genes (including HLA-A, HLA-C, HLA-E, HLA-F, HLA-G, HLA-L, HLA-DMB, HLA-DQA2 and HLA-DRA) showed association with different clinicopathological features in both HCC cohorts. The gene discussed is HLA-L; the disease is hepatocellular carcinoma.